Scientific Publications

Profiles: Google Scholar, Semantic Scholar, ResearchGate, Academia.edu, ORCID
2021
 
Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and optimization efforts
Claire Le Manach, Jean Dam, John G. Woodland, Gurminder Kaur, Lutete P. Khonde, Christel Brunschwig, Mathew Njoroge, Kathryn J. Wicht, André Horatscheck, Tanya Paquet, Grant A. Boyle, Liezl Gibhard, Dale Taylor, Nina Lawrence, Tomas Yeo, Sachel Mok, Richard T. Eastman, Dorjbal Dorjsuren, Daniel C. Talley, Hui Guo, Anton Simeonov, Janette Reader, Mariette van der Watt, Erica Erlank, Nelius Venter, Jacek W. Zawada, Ayesha Aswat, Luisa Nardini, Theresa L. Coetzer, Sonja B. Lauterbach, Belinda C. Bezuidenhout, Anjo Theron, Dalu Mancama, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Sergio Wittlin, Michael Delves, Sabine Ottilie, Elizabeth A. Winzeler, Thomas W. von Geldern, Dennis Smith, David A. Fidock, Leslie J. Street, Gregory S. Basarab, James Duffy and Kelly Chibale, Journal of Medicinal Chemistry, 2021, 64, 2291-2309. DOI: doi.org/10.1021/acs.jmedchem.1c00034

2019
 
Reciprocal modulation of antiretroviral drug and steroid receptor function in vitro
Sigcinile Dlamini, Michael Kuipa, Kim Enfield, Salndave B. Skosana, John G. Woodland, Johnson Mosoko Moliki, Alexis J. Bick, Zephne van der Spuy, Michelle F. Maritz, Chanel Avenant and Janet P. Hapgood, Antimicrobial Agents and Chemotherapy, 2019, 64, e01890. DOI: doi.org/10.1128/AAC.01890-19
 
Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms
Salndave B. Skosana, John G. Woodland, Meghan Cartwright, Kim Enfield, Maleshigo Komane, Renate Louw-du Toit, Zephne van der Spuy, Chanel Avenant, Donita Africander, Karl-Heinz Storbeck and Janet P. Hapgood, Journal of Steroid Biochemistry and Molecular Biology, 2019, 189, 145-153. DOI: doi.org/10.1016/j.jsbmb.2019.02.010
 
2018
 
Chemical proteomics and super-resolution imaging reveal that chloroquine interacts with Plasmodium falciparum multidrug resistance-associated protein and lipids
John G. Woodland, Roger Hunter, Peter J. Smith and Timothy J. Egan, ACS Chemical Biology, 2018, 13, 2939-2948. DOI: doi.org/10.1021/acschembio.8b00583
​Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels
Michelle F. Maritz, Roslyn M. Ray, Alexis J. Bick, Michele Tomasicchio, John G. Woodland, Yashini Govender, Chanel Avenant and Janet P. Hapgood, PLOS ONE, 2018, 13(4), e0196043. DOI: doi.org/10.1371/journal.pone.0196043
 
2017
 
Shining new light on ancient drugs: Preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
John G. Woodland, Roger Hunter, Peter J. Smith and Timothy J. Egan, Organic & Biomolecular Chemistry, 2017, 15, 589-597. DOI: doi.org/10.1039/C6OB02110G
This article was featured on the cover of "Organic & Biomolecular Chemistry" and was identified as a "2017 Hot Article in Organic and Biomolecular Chemistry"

​2013
 
“Fluorescent Sensors for Haem”
T. J. Egan, R. Hunter and J. G. Woodland
Provisional Patent Application SA 2013/05171


​Scientific Presentations