Scientific Publications
2019
Reciprocal modulation of antiretroviral drug and steroid receptor function in vitro
Sigcinile Dlamini, Michael Kuipa, Kim Enfield, Salndave B. Skosana, John G. Woodland, Johnson Mosoko Moliki, Alexis J. Bick, Zephne van der Spuy, Michelle F. Maritz, Chanel Avenant and Janet P. Hapgood, Antimicrobial Agents and Chemotherapy, 2019. DOI: doi.org/10.1128/AAC.01890-19
Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms
Salndave B. Skosana, John G. Woodland, Meghan Cartwright, Kim Enfield, Maleshigo Komane, Renate Louw-du Toit, Zephne van der Spuy, Chanel Avenant, Donita Africander, Karl-Heinz Storbeck and Janet P. Hapgood, Journal of Steroid Biochemistry and Molecular Biology, 2019, 189, 145-153. DOI: doi.org/10.1016/j.jsbmb.2019.02.010
2018
Chemical proteomics and super-resolution imaging reveal that chloroquine interacts with Plasmodium falciparum multidrug resistance-associated protein and lipids
John G. Woodland, Roger Hunter, Peter J. Smith and Timothy J. Egan, ACS Chemical Biology, 2018, 13, 2939-2948. DOI: doi.org/10.1021/acschembio.8b00583
Reciprocal modulation of antiretroviral drug and steroid receptor function in vitro
Sigcinile Dlamini, Michael Kuipa, Kim Enfield, Salndave B. Skosana, John G. Woodland, Johnson Mosoko Moliki, Alexis J. Bick, Zephne van der Spuy, Michelle F. Maritz, Chanel Avenant and Janet P. Hapgood, Antimicrobial Agents and Chemotherapy, 2019. DOI: doi.org/10.1128/AAC.01890-19
Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms
Salndave B. Skosana, John G. Woodland, Meghan Cartwright, Kim Enfield, Maleshigo Komane, Renate Louw-du Toit, Zephne van der Spuy, Chanel Avenant, Donita Africander, Karl-Heinz Storbeck and Janet P. Hapgood, Journal of Steroid Biochemistry and Molecular Biology, 2019, 189, 145-153. DOI: doi.org/10.1016/j.jsbmb.2019.02.010
2018
Chemical proteomics and super-resolution imaging reveal that chloroquine interacts with Plasmodium falciparum multidrug resistance-associated protein and lipids
John G. Woodland, Roger Hunter, Peter J. Smith and Timothy J. Egan, ACS Chemical Biology, 2018, 13, 2939-2948. DOI: doi.org/10.1021/acschembio.8b00583
71 years on, chloroquine is still revealing its secrets: this classic antimalarial associates with membranes while affinity studies expose binding to drug transporter PfMRP1 in the latest from @jgwoodland, et al @UCT_news #TeachingOldDrugsNewTricks https://t.co/53sN1sLTHQ
— ACS Chemical Biology (@ChemicalBiology) October 9, 2018
Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels
Michelle F. Maritz, Roslyn M. Ray, Alexis J. Bick, Michele Tomasicchio, John G. Woodland, Yashini Govender, Chanel Avenant and Janet P. Hapgood, PLOS ONE, 2018, 13(4), e0196043. DOI: doi.org/10.1371/journal.pone.0196043
2017
Shining new light on ancient drugs: Preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
John G. Woodland, Roger Hunter, Peter J. Smith and Timothy J. Egan, Organic & Biomolecular Chemistry, 2017, 15, 589-597. DOI: doi.org/10.1039/C6OB02110G
This article was featured on the cover of "Organic & Biomolecular Chemistry" and was identified as a "2017 Hot Article in Organic and Biomolecular Chemistry"
2013
“Fluorescent Sensors for Haem”
T. J. Egan, R. Hunter and J. G. Woodland
Provisional Patent Application SA 2013/05171
Scientific Presentations
- 2020: Royal Society of Chemistry Twitter Poster Conference (poster presentation)
- 2020: "Advancing Microscopy Frontiers in Africa" Imaging Africa Symposium, University of Cape Town (poster presentation) – Poster Prize
- 2019: "Malaria Research: Crossing Boundaries" international symposium, Stellenbosch University (oral presentation)
- 2019: Royal Society of Chemistry Twitter Poster Conference (poster presentation)
- 2017: Royal Society of Chemistry Twitter Poster Conference (poster presentation)
- 2016: South African Spectroscopy Society (SASS) Young Spectroscopists’ Symposium, Johannesburg (oral presentation)
- 2015: "Seeing is Believing – Imaging the Processes of Life" EMBL Symposium, Heidelberg, Germany (poster presentation)
- 2015: Single-Molecule Spectroscopy and Microscopy: Faraday Discussion, London, United Kingdom (poster and flash oral presentations)
- 2015: South African Chemical Institute Inorganic Chemistry Conference, Rhodes University (poster and flash oral presentations)
- 2015: Postgraduate Research Expo, University of Cape Town (poster presentation) – First Prize (Science Faculty Category)
- 2015: South African Spectroscopy Society (SASS) Young Spectroscopists’ Symposium, Stellenbosch University (oral presentation) – National Winner
- 2014: SACI-ACS Binational Organic Chemistry Conference, Stellenbosch University (poster and flash oral presentation) – First Prize (Flash Oral Category)
- 2013: SACI Young Chemists’ Symposium, Stellenbosch University (poster presentation) – Best Poster Prize
- 2013: International Conference on Bioinorganic Chemistry, Grenoble, France (poster presentation)
- 2012: H3D Symposium "New Paradigms in Drug Discovery", Newlands, Cape Town (poster presentation)
- 2011: SACI Young Chemists’ Symposium, University of the Western Cape (poster presentation) – Best Poster Prize